CXCR4 Antagonist AMD3100 (Plerixafor) Modulates Immune Responses in the Tumor Microenvironment
نویسندگان
چکیده
AMD3100 (Plerixafor), a specific antagonist of CXCR4, is the most potent small molecule non-peptide inhibitor to CXCR4/CXCL12 axis. The chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1) expressed in variety tumor cells play an important role regulating biological behavior. microenvironment (TME) environment around tumor, comprising blood vessels, immune cells, fibroblasts, signaling molecules extracellular matrix which are involved growth, invasion, metastasis, escape eradication.
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ژورنال
عنوان ژورنال: International journal of cancer and clinical research
سال: 2021
ISSN: ['2378-3419']
DOI: https://doi.org/10.23937/2378-3419/1410144